Bedtime is Best

This is what early stage CKD looks like

Ladies and Gentlemen, welcome to the first post of 2012.  Here’s hoping you have the very best year you’ve had to date.

Dr. Kevin Pho started my new year right by posting an except from the book at which is the address for his blog.  I am constantly overwhelmed by the kindess of the medical professionals in helping me with my quest to get the book into the hands of every newly diagnosed CKD patient.

I’ve posted about taking cholesterol medication at night and am doing so myself.  Then I ran across this article from and will explore whether or not to also take hypertension medication at night.  It all makes sense to me, but I would suggest you talk it over with your nephrologist before you make any changes in your medication taking regiment.


Blood Pressure Drugs at Bedtime May Cut Heart Risk

                View the High Blood Pressure (Hypertension) Slideshow Pictures

Latest High Blood Pressure News

Study Suggests Benefits to Taking Blood Pressure Drugs Before Going to Sleep

By Kathleen Doheny WebMD Health News

Reviewed by Laura J. Martin, MD

Oct. 27, 2011 — Taking at least one blood pressure medicine at bedtime cuts the risk of heart problems, according to new research.

The study also shows that participants taking at least one blood pressure pill at bedtime had lower blood pressure while asleep.

Earlier studies have suggested that bedtime dosing of at least one blood pressure medication may help control blood pressure. But the new study is believed to be the first to look at whether the timing makes a difference in terms of heart attacks, strokes, and death.

Ramon C. Hermida, PhD, director of the bioengineering and chronobiology labs at the University of Vigo in Spain, studied 661 people with both high blood pressure and chronic kidney disease.

“Taking blood-pressure-lowering medication at bedtime, compared to [taking] all medication upon awakening, not only improved blood pressure control, but significantly reduced the risk of cardiovascular events,” Hermida says in a news release.

The research appears in the Journal of the American Society of Nephrology.

Timing of Blood Pressure Medicines

Hermida’s team asked half of the men and women to take all their blood pressure medicine when they got up in the morning. On average, each person took two medicines. Many took more than three.

The researchers asked the other half to take at least one of their blood pressure medicines at bedtime.

They measured blood pressure by using 48-hour ambulatory monitoring at the start of the study — not just a single daytime measurement used in most earlier studies. They also measured blood pressure three months after any treatment changes or, at the least, every year.

The researchers followed the men and women for about five and a half years. They looked to see which heart problems developed. They tracked death from any cause and from heart disease or stroke.They also tracked heart attack, angina, heart failure, and other problems.

More than half of those with chronic kidney disease also have high blood pressure, according to the National Kidney Foundation. High blood pressure increases the risk of the kidney disease worsening. Overall, one in three U.S. adults has high blood pressure, according to the researchers.

Bedtime Dosing of Blood Pressure Medicine

Those who took at least one blood pressure medicine at bedtime had lower nighttime blood pressure while asleep. They were also more likely to have overall good control of their blood pressure.

The bedtime group was one-third as likely to have heart and blood vessel problems such as heart attack, stroke, or heart failure, the researchers found.

Improved overnight blood pressure with bedtime dosing had a real benefit. Each 5-point drop in sleep-time blood pressure was linked with a 14% reduction in risk for heart attack, stroke, or heart failure.

“Cardiovascular event rates in patients with hypertension can be reduced by more than 50% with a zero-cost strategy of administering blood pressure-lowering medications at bedtime rather than in the morning,” Hermida says in a news release.

Why Blood Pressure Drugs Work Best at Bedtime

Hermida tells WebMD that some of the body’s blood pressure control systems are most active while we sleep. So medicines designed to control those systems work better when taken close to the time when the systems are activated most fully.

The study results ”make absolute sense to me,” says Robert Graham, MD, MPH, an internist and director of residency research at Lenox Hill Hospital. Graham, an assistant professor of medicine at New York University, reviewed the study findings for WebMD.

”Certain medications have the greatest effect on the body while we sleep,” he says. Indeed, bedtime dosing of blood pressure medications recently has been a hot topic among experts.

Graham has been prescribing blood pressure medicines to be taken at bedtime for years, he says, as it seems to help with the top side effects of blood pressure medicine: fatigue and drowsiness.

“If you do have high blood pressure, and have a hard time getting it [down to your] goal, maybe you should talk with your doctor about changing the time [you take the medicine],” he says.

SOURCES: Journal of the American Society of Nephrology, published online Oct. 24, 2011.Ramon Hermida, PhD, director, bioengineering and chronobiology labs, University of Vigo, Pontevedra, Spain.Robert Graham, MD, MPH, director of residency research, Lenox Hill Hospital; assistant professor of medicine, New York University. ©2011 WebMD, LLC. All Rights Reserved.

You can find the original article at:

Many, many hopes for a happy new year.  Join us for the upcoming TwitterChat on Jan. 9 from 8-9 EST at #LibreChat.  If you’re local, schedule in the book signing at Bookman’s in Mesa on Saturday, Jan. 14 from 1-3.  I really enjoy meeting my readers and their friends and family.  One person seems even more interesting than the other!

Until next week,

Keep living your life!

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2 CommentsLeave a comment

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    • Thank you for your kind comments. I found your comment mixed in with the spam. I can’t imagine why anyone would receive so much spam, but I do. I think I’m beginning to learn the difference between the two. Are you English? I see that in your spelling. You can see who I am at: Welcome to the blog.

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