On the Sea, On the Sea, On the Beautiful Sea

What a week!  All the aspects of the Phoenix Kidney Walk have been completed, although you can still donate to Team SlowItDownCKD at kidneywalk.kintera.org until May 31st.  No, this is not a solicitation, but rather information for those of you who had asked for it. 2015-04-18 22.02.52

I thought you might like to see some of the pictures so here they are sprinkled throughout today’s blog – with thanks to Keith Harris for being our impromptu (and talented) photographer. Most of the members of our team were too busy walking to stay still for photos, but they were there. That’s Keith Harris, Patti DuBois & me in the photo above.

This allowed me to slow it down a bit myself.  So much so that I started finalizing the plans for the cruise to Vancouver, B.C. and Alaska that’s my gift to Bear for our second anniversary. (Finally, our long awaited honeymoon!) One of the things my very-experienced-at-cruising sister-in-law, Judy Peck, told me about is anti-motion sickness medication.  And, of course, my first reaction was, “I’ll have to research that for Chronic Kidney Disease.”  The banner picture is of my daughter, Abby Wegerski, on the left and me on the right.

2015-04-18 22.09.45

First I went to the UK site ‘Patient’ at http://www.patient.co.uk/medicine/cyclizine-for-sickness for the definition of what is commonly known as sea sickness or, as the English call it, travel sickness. This site has the some of the most reader friendly explanations for medical issues.

Nerves situated inside your ear send messages to your brain with information about your movement. Along with messages from your eyes and muscles, these nerves help your body to maintain a good sense of balance. If the nerves in one of your ears send too many, too few, or wrong messages to your brain, it conflicts with the messages sent from your other ear, your eyes, or your body. Your brain then gets confused and this can cause dizziness and vertigo (a spinning sensation), and can make you feel sick.

Travel sickness is caused by repeated unusual movements during travelling. These repeated movements, such as going over bumps or around in a 2015-04-18 21.41.32  circle, send lots of messages to your brain. The balance mechanism in your ear sends different signals to those from your eyes, which  results in your brain receiving mixed and confusing messages. This is what causes you to feel sick.

That’s a picture of my young friend and pooper scooper/dog sitter, Willie Vlasity and Mr. Taco Bell.

Makes sense.  Now, what can we do about it? According to MedicineNet at     http://www.medicinenet.com/motion_sickness_sea_sickness_car_sickness/page3.htm,

Over-the-counter medications, and occasionally prescription medications, are used to relieve and in some cases prevent motion sickness. Some of the more common medications that can be used for motion sickness include:

Scopolamine (transdermal patches, Transderm-Scop)2015-04-18 21.08.28

dimenhydrinate (Dramamine)

meclizine (Antivert, Bonine, Meni-D, Antrizine)

promethazine (Phenergan, Phenadoz, Promethegan)

diphenhydramine (Benadryl)

cyclizine (Marezine)

Notice Patti made a new friend, too.

Wonderful, except that when I researched each of these on different sites, this is what I found. By the way, the bolding and italicizing are mine.

2015-04-18 21.39.40

Lara Garwood, my step-daughter, helped me show off our team t-shirts.

At MedlinePlus, A service of the U.S. National Library of Medicine from the National Institutes of Health National Institutes of Health (http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682509.html),

Before using scopolamine patches… tell your doctor if you have or have ever had glaucoma; heart, liver, or kidney disease; stomach or intestinal obstruction; or difficulty urinating.

From Drugs.com at http://www.drugs.com/disease-interactions/dimenhydrinate,dramamine.html about dimenhydrinate, better known as Dramamine (including less drowsy),

Limited pharmacokinetic data are available for the older, first-generation antihistamines. Many appear to be primarily metabolized by the liver, and both parent drugs and metabolites are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from antihistamines due to drug and metabolite accumulation. Therapy with antihistamines should be administered cautiously in such patients. Lower initial dosages may be appropriate.

On the contrary, MedicineNet.com at http://www.medicinenet.com/meclizine/index.htm does not list kidney disease at all for meclizine.  Although, there is a warning against alcohol use while using this medication.

2015-04-18 20.55.37

Isn’t that a wonderful entry to the National Kidney Foundation of Arizona Phoenix Kidney Walk?

Trying to use as many varied sources as possible, I went to WebMD at http://www.webmd.com/drugs/2/drug-8895/promethazine-oral/details for information on promethazine.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD, sleep apnea), blood/immune system problems (such as bone marrow depression), high pressure in the eye (glaucoma), heart disease (such as irregular heartbeat), high blood pressure, liver disease, certain brain disorders (such as neuroleptic malignant syndrome, Reye’s syndrome, seizures), stomach/intestine problems (such as blockage, ulcer), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate).

True, there is no warning against using promethazine if you have CKD, but how many of us who do also have sleep apnea and/or high blood pressure – the second most common cause of CKD.

Back to Medicinenet.com for the following about diphenhydramine at http://www.medicinenet.com/diphenhydramine/article.htm.

Diphenhydramine should be used with caution (if at all) in persons with narrow-angle glaucoma, prostatic hypertrophy (enlarged prostate gland), hyperthyroidism, cardiovascular disease, high blood pressure (hypertension), and asthma.

motion sickness

And what about cyclizine?  Everydayhealth.com at http://www.everydayhealth.com/drugs/cyclizine has no warnings about taking this if you have kidney disease.  There was one line in the how to take it section that just, plain cracked me up.  See if you get a good laugh out of this, too.

The chewable tablet must be chewed before you swallow it.

Let’s look into the two without any CKD warnings a bit more. Uh-oh, the British version of WebMD at http://drugs.webmd.boots.com/drugs/drug-137-Cyclizine.aspx tells us something different about cyclizine than the U.S. version of the same website.

Cyclizine should be used with caution in:

People with glaucoma (increased pressure in the eye)

People with obstructive disease of the stomach

People with liver disease

People with epilepsy (fits)

Males with prostatic hypertrophy (enlargement of prostate gland)

People with severe heart failure

People with decreased kidney functionncl

Pregnant women

Women breastfeeding

The elderly

As for meclizine, even the U.S. version of WebMD says emphatically “Consult your doctor.”

In all honesty, I wouldn’t take any medication without consulting my doctor – specifically my nephrologist.  I urge you to do the same.

Let’s say I was sufficiently spooked by today’s blog to not even want to try medication.  Is there something I could use to prevent sea sickness that’s not medication?  Of course, there is. Many people swear by these remedies, but that’s next week’s blog, folks.

Thank you so much for participating in the prize giveaways for each of the books.  As I saw each prize claimed, all I could think was, “Look how many people are going to share their awareness of Chronic Kidney Disease.”

Book Cover

Until next week,Part 2Digital Cover Part 1

Keep living your life!


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